HERO-HCQ Trial


Susanna Naggie, MD
HERO-HCQ Trial, Principal Investigator

“It’s important that we assess the effectiveness of hydroxychloroquine in healthcare workers, not only for their own safety but also to prevent further spread of COVID-19 as they care for patients.”


Susanna Naggie, MD
HERO-HCQ Trial, Principal Investigator

Read the HERO-HCQ protocol.

Healthcare Worker Exposure Response & Outcomes of Hydroxychloroquine Trial (HERO-HCQ)

HERO-HCQ is a randomized clinical trial of approximately 15,000 HERO Registry participants. It will test whether hydroxychloroquine (HCQ, brand name Plaquenil®) can prevent COVID-19 infection in healthcare workers.

The possible benefits of taking HCQ for healthcare workers who may be at risk for COVID-19 infection are not fully understood. We need evidence, and who better to help generate that evidence than healthcare workers?

Why hydroxychloroquine?

Hydroxychloroquine is approved by the U.S. Food and Drug Administration to treat malaria and certain conditions such as rheumatoid arthritis and lupus. In HERO-HCQ, we will test its use to prevent COVID-19 infection.

Read, download, and share this flyer on what we know and don't know about hydroxychloroquine.

How do I participate in the HERO-HCQ trial?

To take part in any HERO research, you must first join the HERO Registry. To take part in the HERO-HCQ Trial, you must be invited to participate by one of the approximately 40 U.S. clinical research sites in PCORnet®, the National Patient-Centered Clinical Research Network.

What's involved?

  • Attend an initial visit as well as a follow-up in-person visit.
  • Provide a nasal swab for COVID-19 testing and a blood sample at the initial visit and follow-up visit.
  • Be assigned to take either HCQ (study drug) or a placebo for 30 days.
  • Complete weekly online surveys related to health, mood, and COVID-19 exposure.

What you can expect if you decide to participate

  • An opportunity to contribute knowledge on how to prevent COVID-19 infection in healthcare workers.
  • Your study doctor will tell you if you have a positive COVID-19 result from the nasal swab testing by the end of the study.
  • A summary of the overall trial results once the final results are available. This summary will be posted on heroesresearch.org.

How long is the trial?

Eight weeks